Cloning in cattle: from embryo splitting to somatic nuclear transfer
نویسندگان
چکیده
منابع مشابه
Cloning in cattle: from embryo splitting to somatic nuclear transfer.
The ability to obtain genetically identical offspring in cattle (clones) is useful for research and for potential applications to breeding schemes. Experimental possibilities for generating such animals have evolved considerably in the last two decades. Embryo splitting has become a relatively simple technique but is limited to twinning. Embryonic nuclear transfer has improved and is associated...
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Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...
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Within 2 years of the announced birth in 1997 of Dolly, the lamb cloned from the mam-mary cells of an adult ewe, research groups announced that they had cloned mice and calves by using differentiated somatic cells (1– 3). In the cloning technique used to produce Dolly, the nucleus of a somatic cell of the ewe was transferred to a sheep oocyte from which the nucleus had been removed, and the cel...
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Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering technology that endows the somatic cell genome with totipotency. Since the first report on the birth of a cloned sheep from adult somatic cells in 1997, many technical improvements in SCNT have been made by using different epigenetic approaches, including enhancement of the levels of histone acetylation in the chr...
متن کاملCloning animals by somatic cell nuclear transfer – biological factors
Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. However, somatic cloning has been inefficient in all species in which live clones have been produced. High abortion and fetal mortality rates are commonly observed. These developmental defects have been attributed to incomplete reprogramming of the somatic nuclei by the cloning process. Various strateg...
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ژورنال
عنوان ژورنال: Reproduction Nutrition Development
سال: 1998
ISSN: 0926-5287
DOI: 10.1051/rnd:19980602